The subiculum sensitizes retrosplenial cortex layer 2/3 pyramidal neurons

Key points Neurons in the retrosplenial cortex (RSC), a cerebral region that connects synaptically with various brain regions, are known to increase neuronal activity accordance hippocampal sharp wave-ripples. Pyramidal cells granular RSC (gRSC) layer 2/3, but not 5, exhibit slowly ramping depolarization and considerably delayed spikes response step-pulse current injection. The latencies of 2/3 pyramidal neurons were shortened by preceding This effect was mimicked activation axonal afferents from subiculum, neocortical afferents. subiculum is likely facilitate information processing flow RSC. Abstract involved diverse cognitive functions, an anatomical hub forms monosynaptic connections areas. Here, we report unique form short-term intrinsic plasticity mouse cells. These exhibited somatic injection, spike brief (priming). priming-induced sensitization distinct desensitization, which commonly observed other cortical neurons. facilitatory priming lasted for more than 3 s, providing time window increased sensitivity inputs. Based on vitro vivo patch-clamp recordings following optogenetic stimulation fibres, found preactivation subicular replicated effect. results suggest inputs may modulate subsequent integration circuits.